Advances in stem cell therapy for amyotrophic lateral sclerosis.
Stem Cell Implications for ALS (Amyotrophic Lateral Sclerosis)2017 come 2017 bastardi senza gloria trama
Stem cells have the ability to divide for indefinite periods in culture and give rise to multiple specialized cell types. They can develop into blood, neurons, bone, muscle, skin and other cell types. They have emerged as a major tool for research into the causes of ALS, and in the search of new treatments.
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Don't miss out! Create your free JWatch. Richard A. Ann Neurol Jul The mean changes in the ALSFRS-R from baseline to 4 and 6 months, the primary endpoint, were significantly smaller in the MSC group than the control group; the between-group difference was 2.
Stem Cell Therapy for ALS
Webinar: Injection of Neural Stem Cells in Patients with ALS: Results of a Phase I Clinical Trial
ALS is a devastating disease for which there is no treatment or cure. Progression from early muscle twitches to complete paralysis and death usually happens within 4 years. In California the death rate is one person every one and a half days. Stem cells have been shown to produce support cells for dying motor neurons called astrocytes which may slow down disease progression. Furthermore, many studies have shown that growth factors such as glial cell line-derived growth factor or GDNF can protect motor neurons from damage in a number of different animal models including those for ALS. However, delivering GDNF to the spinal cord has been almost impossible as it does not cross from the blood to the brain tissue.